Crystallization of the human tetraspanin protein CD9
نویسندگان
چکیده
منابع مشابه
Tetraspanin CD9 in cell migration.
Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, including phosphorylation of FAK (focal adhesion kinase) and activation of phosphoinositide 3-kinase, p38 MAPK (mitogen-activated protein kinase) an...
متن کاملDistribution of tetraspanin family protein CD9 in bull reproductive system
The CD9 cell surface molecule has been found to be important for the fertilization process of mammals. The aim of this study was to investigate, whether the molecule CD9 is expressed on bull sperm during the spermatogenesis and maturation of spermatozoa as well as in bull reproductive organs and their secreta. The expression of bovine CD9 was examined by immunohistochemistry, immunofluorescence...
متن کاملThe C-terminal tail of tetraspanin protein CD9 contributes to its function and molecular organization.
Tetraspanin protein CD9 supports sperm-egg fusion, and regulates cell adhesion, motility, metastasis, proliferation and signaling. The large extracellular loop and transmembrane domains of CD9 engage in functionally important interactions with partner proteins. However, neither functional nor biochemical roles have been shown for the CD9 C-terminal tail, despite it being highly conserved throug...
متن کاملTetraspanin CD9 Promotes the Invasive Phenotype of Human Fibrosarcoma Cells via Upregulation of Matrix Metalloproteinase-9
Tumor cell metastasis, a process which increases the morbidity and mortality of cancer patients, is highly dependent upon matrix metalloproteinase (MMP) production. Small molecule inhibitors of MMPs have proven unsuccessful at reducing tumor cell invasion in vivo. Therefore, finding an alternative approach to regulate MMP is an important endeavor. Tetraspanins, a family of cell surface organize...
متن کاملRole of tetraspanin CD9 molecule in fertilization of mammals.
Fertilization process is a very clever and unique process comprising some essential steps resulting in formation of zygote. Tetraspanin CD9 is considered to be a serious candidate molecule participating in these events. The importance of CD9 has been discussed in relation to acrosome reaction, sperm-binding, sperm-penetration, sperm-egg fusion and eventually, egg activation. The abundant expres...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section F Structural Biology Communications
سال: 2019
ISSN: 2053-230X
DOI: 10.1107/s2053230x1801840x